{micro}-Opioid Receptor Gene (OPRM1) Polymorphism A118G: Lack of Association in Finnish Populations with Alcohol Dependence or Alcohol Consumption

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  1. Noora Rouvinen-Lagerström1,
  2. Jari Lahti2,
  3. Hannu Alho1,3,
  4. Leena Kovanen1,
  5. Mauri Aalto1,4,
  6. Timo Partonen1,
  7. Kaisa Silander5,
  8. David Sinclair1,
  9. Katri Räikkönen2,
  10. Johan G. Eriksson6,7,8,9,
  11. Aarno Palotie10,11,12,
  12. Seppo Koskinen13 and
  13. Sirkku T. Saarikoski1,*
  1. 1Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
  2. 2Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
  3. 3Institute of Clinical Medicine, Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  4. 4Department of Psychiatry, South Ostrobothnia Hospital District, Seinäjoki, Finland
  5. 5Unit of Public Health Genomics, National Institute for Health and Welfare, and Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland
  6. 6National Institute for Health and Welfare, Helsinki, Finland
  7. 7Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
  8. 8Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
  9. 9Folkhälsan Research Centre, Helsinki, Finland
  10. 10Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
  11. 11Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
  12. 12Broad Institute of Harvard and MIT, Cambridge, USA
  13. 13Department of Health, Functional Capacity and Welfare, National Institute of Health and Welfare, Helsinki, Finland
  1. *Corresponding author: Ministry of Social Affairs and Health, Department of Occupational Safety and Health, PO Box 33, FI-00023 Government, Finland; Tel.: +358-295163565; E-mail sirkku.saarikoski{at}stm.fi
  • Received February 26, 2013.
  • Revision requested March 30, 2013.
  • Revision received April 17, 2013.
  • Accepted April 24, 2013.

Abstract

Aims: The molecular epidemiological studies on the association of the opioid receptor µ-1 (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) and alcohol use disorders have given conflicting results. The aim of this study was to test the possible association of A118G polymorphism and alcohol use disorders and alcohol consumption in three large cohort-based study samples. Methods: The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384). The latter two populations lacked diagnosis-based phenotypes, but included detailed information on alcohol consumption. Results: We found no statistically significant differences in genotypic or allelic distribution between controls and subjects with alcohol dependence or abuse diagnoses. Likewise no significant effects were observed between the A118G genotype and alcohol consumption. Conclusion: These results suggest that A118G (Asn40Asp) polymorphism may not have a major effect on the development of alcohol use disorders at least in the Finnish population.

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