Metabolic Abnormalities in Lobar and Subcortical Brain Regions of Abstinent Polysubstance Users: Magnetic Resonance Spectroscopic Imaging

Skip Navigation

  1. Christoph Abé1,2,
  2. Anderson Mon1,2,
  3. Michael E. Hoefer1,2,
  4. Timothy C. Durazzo1,2,
  5. David L. Pennington1,2,
  6. Thomas P. Schmidt1,2 and
  7. Dieter J. Meyerhoff1,2,*
  1. 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
  2. 2Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, San Francisco, CA, USA
  1. *Corresponding author: Center for Imaging of Neurodegenerative Diseases, Veterans Administration Medical Center, 4150 Clement Street, 114M, San Francisco, CA 94121, USA. Tel.: +1-415-221-4810; Fax: +1-415-668-2864; E-mail: dieter.meyerhoff{at}
  • Received February 6, 2013.
  • Revision requested March 19, 2013.
  • Revision received May 22, 2013.
  • Accepted May 24, 2013.


Aims: The aim of the study was to explore neurometabolic and associated cognitive characteristics of patients with polysubstance use (PSU) in comparison with patients with predominant alcohol use using proton magnetic resonance spectroscopy. Methods: Brain metabolite concentrations were examined in lobar and subcortical brain regions of three age-matched groups: 1-month-abstinent alcohol-dependent PSU, 1-month-abstinent individuals dependent on alcohol alone (ALC) and light drinking controls (CON). Neuropsychological testing assessed cognitive function. Results: While CON and ALC had similar metabolite levels, persistent metabolic abnormalities (primarily higher myo-inositol) were present in temporal gray matter, cerebellar vermis and lenticular nuclei of PSU. Moreover, lower cortical gray matter concentration of the neuronal marker N-acetylaspartate within PSU correlated with higher cocaine (but not alcohol) use quantities and with a reduced cognitive processing speed. Conclusions: These metabolite group differences reflect cellular/astroglial injury and/or dysfunction in alcohol-dependent PSU. Associations of other metabolite concentrations with neurocognitive performance suggest their functional relevance. The metabolic alterations in PSU may represent polydrug abuse biomarkers and/or potential targets for pharmacological and behavioral PSU-specific treatment.

Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.